Forty Years Since the Unsolved Tylenol Murders

This article is about the unsolved Tylenol and copycat poisonings with cyanide in painkiller capsules. My involvement in the case was as an analytical chemist to develop rapid methods for analyses of the potentially millions of suspect products recalled from shelves of drugstores. The hope was that such chemical testing might give clues to investigators concerning the distribution of tainted products that could lead to an arrest.

It’s been 40 years since seven people died from cyanide poisoning from adulterated extra-strength Tylenol tablets. The victims had purchased bottles of Tylenol, on store shelves, in suburban Chicago. A completely ordinary thing to do. They were tragically unaware of tampering by an unknown attacker who had replaced the contents of the pills with cyanide [1]. It was a shocking incident that completely changed sales and production of pharmaceuticals. Today, we take for granted the safety of drugs and medicines because they’re produced in tamper-evident blister packs or sealed bottles. This was not the case before 1982.

Unfortunately, this incident attracted copycat attacks in the years that followed. It was after such a copycat attack in 1984, this time on a different brand of painkillers in Westchester County, NY, that I became involved. I was at Indiana University, Department of Chemistry, Bloomington IN and I had become friends with my office-mate, now Professor Robert Lodder (at the University of Kentucky, College of Pharmacy). Rob was working on combining Near-infrared Spectroscopy with intelligent algorithms, using statistics and mathematics, for an enhanced interpretation of the data.

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